Glucosamine Sulfate is a factor in the building of healthy cartilage and it protects against joint deterioration while reducing or eliminating pain and improving joint function. Glucosamine has been shown since its first clinical studies in 1980 to be effective in easing pain and discomfort associated with arthritis. Studies have shown that supplementing with Glucsoamine sulfate may stimulate joint repair. It is generally believed that the sulfur component makes it more useful for joint problems.